Systematics of type IIB moduli stabilisation with odd axions

Moduli stabilisation in superstring compactifications on Calabi-Yau orientifolds remains a key challenge in the search for realistic string vacua. In particular, odd moduli arising from the reduction of 2-forms (B2, C2) in type IIB are largely unexplored despite their relevance for inflationary model building. This article provides novel insights into the general structure of 4D N = 1 F-term scalar potentials at higher orders in the α′ and gs expansion for arbitrary Hodge numbers. We systematically examine superpotential contributions with distinct moduli dependences which are induced by fluxes or non-perturbative effects. Initially, we prove the existence of a no-scale structure for odd moduli in the presence of (α′)3 corrections to the Kähler potential. By studying a partially SL(2, ℤ)-completed form of the Kähler potential, we derive the exact no-scale breaking effects at the closed string 1-loop and non-perturbative D-instanton level. These observations allow us to present rigorous expressions for the F-term scalar potential applicable to arbitrary numbers of moduli in type IIB Calabi-Yau orientifold compactifications. Finally, we compute the Hessian for odd moduli and discuss potential phenomenological implications

Demonstration of astrocytes in cultured amniotic fluid cells of three cases with neural-tube defect

We have investigated the origin of rapidly adhering (RA) cells in three cases of neural tube defects (two anencephali, one encephalocele). We were able to demonstrate the presence of glial fibrillary acidic (GFA) protein in variable percentages (4–80%) of RA cells cultured for 4–6 days by use of indirect immunofluorescence with GFA antiserum. Cells cultured from amniotic fluids of normal pregnancies and fetal fibroblasts were completely GFA protein negative. GFA protein is well established as a highly specific marker for astrocytes. Demonstration of astrocytes may prove to be a criterion of high diagnostic value for neural tube defects. The percentage of astrocytes decreased with increasing culture time, while the percentage of fibronectin positive cells increased both in amniotic fluid cell cultures from neural tube defects and normal pregnancies

The association between national culture, road safety performance, and support for road safety policy measures

There are considerable differences between countries when it comes to road safety performance, as indicated by the number of road fatalities per 100,000 inhabitants. These discrepancies are strongly associated with differences in wealth and prosperity, as expected, but are also related to national culture. The overall objective of this exploratory study is to identify relationships between national culture, road safety performance and public support for policy measures. Using the revised version of Hofstede's cultural dimensions, we show the strong correlation between national culture and road safety performance, which exists even after controlling for the national level of wealth as measured by the gross national income. Furthermore, by combining the national cultural dimensions with data on 29 countries from the second stage of ESRA, the E-Survey of Road users' Attitudes, this study demonstrates that culture also affects the level of public support for policy measures related to road safety. Specifically, for many measures, the degree of individualism accounts for a considerable part of the statistical variation in the public support for policy measures across countries—except for those measures for which the support is very high in most countries. Possible explanations are given for the seemingly paradoxical finding that countries which witness high resistance to road safety policy measures have nevertheless managed to achieve better road safety performance

Neural cell adhesion molecule-mediated fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex

GABAergic basket interneurons form perisomatic synapses, which are essential for regulating neural networks, and their alterations are linked to various cognitive dysfunction. Maturation of basket synapses in postnatal cortex is activity dependent. In particular, activity-dependent downregulation of polysialiac acid carried by the neural cell adhesion molecule (NCAM) regulates the timing of their maturation. Whether and how NCAM per se affects GABAergic synapse development is unknown. Using single-cell genetics to knock out NCAM in individual basket interneurons in mouse cortical slice cultures, at specific developmental time periods, we found that NCAM loss during perisomatic synapse formation impairs the process of basket cell axonal branching and bouton formation. However, loss of NCAM once the synapses are already formed did not show any effect. We further show that NCAM120 and NCAM140, but not the NCAM180 isoform, rescue the phenotype. Finally, we demonstrate that a dominant-negative form of Fyn kinase mimics, whereas a constitutively active form of Fyn kinase rescues, the effects of NCAM knockdown. Altogether, our data suggest that NCAM120/NCAM140-mediated Fyn activation promotes GABAergic synapse maturation in postnatal cortex

Spontaneous Motor Entrainment to Music in Multiple Vocal Mimicking Species

SummaryThe human capacity for music consists of certain core phenomena, including the tendency to entrain, or align movement, to an external auditory pulse [1–3]. This ability, fundamental both for music production and for coordinated dance, has been repeatedly highlighted as uniquely human [4–11]. However, it has recently been hypothesized that entrainment evolved as a by-product of vocal mimicry, generating the strong prediction that only vocal mimicking animals may be able to entrain [12, 13]. Here we provide comparative data demonstrating the existence of two proficient vocal mimicking nonhuman animals (parrots) that entrain to music, spontaneously producing synchronized movements resembling human dance. We also provide an extensive comparative data set from a global video database systematically analyzed for evidence of entrainment in hundreds of species both capable and incapable of vocal mimicry. Despite the higher representation of vocal nonmimics in the database and comparable exposure of mimics and nonmimics to humans and music, only vocal mimics showed evidence of entrainment. We conclude that entrainment is not unique to humans and that the distribution of entrainment across species supports the hypothesis that entrainment evolved as a by-product of selection for vocal mimicry

The Standard Model quiver in de Sitter string compactifications

We argue that the Standard Model quiver can be embedded into compact Calabi-Yau geometries through orientifolded D3-branes at del Pezzo singularities dPn with n ≥ 5 in a framework including moduli stabilisation. To illustrate our approach, we explicitly construct a local dP5 model via a combination of Higgsing and orientifolding. This procedure reduces the original dP5 quiver gauge theory to the Left-Right symmetric model with three families of quarks and leptons as well as a Higgs sector to further break the symmetries to the Standard Model gauge group. We embed this local model in a globally consistent Calabi-Yau flux compactification with tadpole and Freed-Witten anomaly cancellations. The model features closed string moduli stabilisation with a de Sitter minimum from T-branes, supersymmetry broken by the Kähler moduli, and the MSSM as the low energy spectrum. We further discuss phenomenological and cosmological implications of this construction

Nuclear factor I-A represses expression of the cell adhesion molecule L1

<p>Abstract</p> <p>Background</p> <p>The neural cell adhesion molecule L1 plays a crucial role in development and plasticity of the nervous system. Neural cells thus require precise control of L1 expression.</p> <p>Results</p> <p>We identified a full binding site for nuclear factor I (NFI) transcription factors in the regulatory region of the mouse <it>L1 </it>gene. Electrophoretic mobility shift assay (EMSA) showed binding of nuclear factor I-A (NFI-A) to this site. Moreover, for a brain-specific isoform of NFI-A (NFI-A bs), we confirmed the interaction <it>in vivo </it>using chromatin immunoprecipitation (ChIP). Reporter gene assays showed that in neuroblastoma cells, overexpression of NFI-A bs repressed L1 expression threefold.</p> <p>Conclusion</p> <p>Our findings suggest that NFI-A, in particular its brain-specific isoform, represses <it>L1 </it>gene expression, and might act as a second silencer of L1 in addition to the neural restrictive silencer factor (NRSF).</p